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Subacute sclerosing panencephalitis (SSPE): Late onset of measles complication - Case of IVIG treatment failure

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Case Report

Author Details : Athira Mohan S*, Anoop V Somarajan, Dhanya Dharman

Volume : 9, Issue : 2, Year : 2023

Article Page : 69-71

https://doi.org/10.18231/j.ijashnb.2023.013

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Abstract

Subacute sclerosing panencephalitis (SSPE) is characterized by gradual deterioration of cognitive motor and cognitive functions. SSPE more often occurs in individuals who had a history of measles viral infection. We present a case of 8 year old male child who was presented with generalized progressive weakness, recurrent falls to one side, multiple episodes of seizure, urinary incontinence. On liaison it was understood that he had a history of measles at the age of 3 years. Examination showed elevated serum measles antibody titer, electro-encephalogram (EEG) analysis revealed stereotyped polymorphic discharge seen periodically, suggestive of SSPE. He was treated with IVIG and other symptomatic treatment. However he had recurrent episodes of vomiting after IVIG administration, Ribavirin administration caused multiple oral lesions. Upon discharge he was given Syr. Valproate, Oral Steroid (Prednisolone) tapering therapy, THP 2 mg BD, PPI and Laxatives. Parents were advised to maintain RT feed of 150 mL, once in 3 hours. After 1 week, he succumbed to his illness at his residence.
 

Keywords: Subacute sclerosing panencephalitis (SSPE), Electro­encephalogram (EEG), IVIG, Serum measles antibody titer

How to cite : Athira Mohan S, Somarajan A V, Dharman D, Subacute sclerosing panencephalitis (SSPE): Late onset of measles complication - Case of IVIG treatment failure. IP Indian J Anat Surg Head Neck Brain 2023;9(2):69-71

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