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The role of neoadjuvant chemotherapy in LABC – A multicentric study

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Original Article

Author Details : Rupa M. Mascarenhas, Manish Kumar, Elroy Saldanha, Sheldon Mathias*, Rachan Shetty

Volume : 5, Issue : 2, Year : 2019

Article Page : 59-60

https://doi.org/10.18231/j.ijashnb.2019.015

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Abstract

Introduction: LABC accounts for 10-20% in the West, while in India, it accounts for 30-60% of all cases. LABC encompasses a wide spectrum of malignant breast tumors with varying presentation and poses a significant therapeutic challenge. Locally advanced breast cancer presents with a difficult management problem. It remains a challenge to achieve local and distant control of locally advanced breast cancer. Locally advanced breast cancer presents with a difficult management problem. It remains a challenge to achieve local and distant control of locally advanced breast cancer neoadjuvant chemotherapy in LABC.
Materials and Methods: A prospective, non-interventional study was done on multiple centres in the district of Dakshina Kannada  on 100 adult patients admitted in who either presented with histological confirmed locally advanced breast cancer were be included in the study as per the following criteria between June  2014 to  May  2019. After this preoperative work up all patients. We used AC regimen in 120 patients. The Response to chemotherapy was studied in all patients who received neo adjuvant chemotherapy according to the Response Evaluation Criteria in Solid Tumors published in February 2000 by European Organization for Research and Treatment of Cancer was used to evaluate the tumor response The patients are followed up for a period of minimum of 3 years and maximum 2 years and at regular intervals during each cycle of chemotherapy. Clinical examination in details about the tumor characteristics and change in size of tumor with status of axillary LN had been entered in the database. After completion of NACT all patients assess for operability and underwent modified radical mastectomy. The surgical specimens removed from all the patients are sent for histopathology examination in the pathology section and are studied for Pathological response and Histological grade.
Observations and Results: In the present study, the age of the cases in the study ranged from 22 years to 79 years, 56.72 years SD + 15 years; the most common age group was 40-55 years 48% of the entire study population. Less than 25 years we had 2 cases between 25-35 we had 12 cases all had a family history of cancer. 78% used OPS for contraception. Clinical and pathological complete response was seen more commonly in Her2 subtype cases. NACT could downstage the disease so as to make the inoperable tumor to operable one and possible to resect locally advanced disease.

Keywords: Clinical, Neoadjuvant, Pathological, Locally advanced breast cancer.

How to cite : Mascarenhas R M, Kumar M, Saldanha E, Mathias S, Shetty R, The role of neoadjuvant chemotherapy in LABC – A multicentric study. IP Indian J Anat Surg Head Neck Brain 2019;5(2):59-60

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