IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain

Print ISSN: 2581-5210

Online ISSN: 2581-5229

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IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain (IJASHNB) open access, peer-reviewed quarterly journal publishing since 2015 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing more...

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Get Permission Gatty, Shet, and D’souza: An analysis of the demography and histology of patients presenting with oral cavity malignancy


Introduction

In the modern world one of the most dreaded disease is cancer. Among all the cancers that occur, cancer within the oral cavity ranks as the eleventh most common cancer globally.1, 2

It is estimated that oral malignancies most often affect those countries that have low and middle income, and 50% of these cancers occur in the South East Asian countries particularly in the Indian subcontinent.3, 4, 5

In view of the changing trends in oral cancer we did a study to evaluate the practices followed for oral cancer in our study.

Materials and Methods

The present study was a non-randomized prospective observational study that was done on patients who visited hospital and were diagnosed by histopathology as having oral cancer. The study was done at the department of general surgery and surgical oncology at the Father Muller Medical College .Kankanady in the state of Karnataka South India. The study was done. During the study period that extended from March 2014 to February 2020 the following observations were done on a total of 202 cases.

Those who met a predefined criteria and gave a written informed consent were enrolled in the study. They were explained regarding their disease, the treatment options that are available and the alternative treatments if any.

Once the patients was optimized, based on the decision of the tumour board appropriate therapy was given and the complications of each was noted down.

Results

During the study period that extended from March 2014 to February 2020 the following observations were done on a total of 202 cases.

Table 1

Age distribution in the study subjects

Age Frequency Percentage
Less than 21 2 0.99%
21-30 years 32 15.84%
31-40 years 46 22.77%
1-50 years 68 33.66%
51-60 years 36 17.82%
61-70 years 16 7.92%
>71 years 2 0.99%
Total 202 100.00%

In the present study between the age of 20 and 60 years we had 148 cases (73.26%), the most common decade involved was 41-50 years with 68 cases (33.66%).

In the productive age group between the age of 21 years and 50 years we had 146 cases.

Table 2

gender distribution in the study subjects

Gender Frequency Percentage
Male 164 81.19%
Female 38 18.81%
Total 202 100.00%

The predominant population affected by oral cancer was male’s 164 cases (81.19%).

On evaluation of the clinical presentation distribution in the study subjects all cases presented with ulcer.

Table 3

Distribution of the site of lesion in the study subjects

Site Frequency Percentage
Buccal mucosa 2 0.99%
Tongue 200 99.01%
Total 202 100.00%

Lesions of the tongue were seen in 99.01% cases.

Table 4

Distribution of the surgical management in the study subjects

Surgical management Frequency Percentage
Hemimanibulectomy +Subtotal Glossectomy+Mrnd 1 0.99%
IDL + Biopsy 6 5.94%
ECA Ligation 3 2.97%
Near Glossectomy +MRND 1 0.99%
Hemi Glossectomy +MRND 16 15.84%
Partial Glossectomy +MRND 7 6.93%
Resection +MRND 1 0.99%
Subtotal Glossectomy +MRND 7 6.93%
Total Glossectomy+MRND 20 19.80%
W ,SOHND 5 4.95%
W+MRND 34 33.66%
W+MRND+F 5 4.95%
Total 101 100.00%

In most cases wide excision and reconstruction was possible (54 cases) near glossectomy with MRND was done in 1patient hemi glossectomy with MRND was done in 16 patient partial glossectomy with MRND was done in 17 patient.

All case were proved as Squamous cell carcinoma. the minimum follow up was for 13 months and at the last follow-up all cases were found to be tumour free.

Discussion  

Recent data has suggested that an annual basis approximately three million new cases are noted and half of them succumb to the disease. 1, 2

Among all sites within the oral cavity the cancer of the tongue holds a special place and most often is described as a separate clinical entity. 3, 4

It is estimated that oral malignancies most often affect those countries that have low and middle income, and 50% of threes cancers occur in the South East Asian countries particularly in the Indian subcontinent. India is holds a top position in the epidemiology of oral cancers and accounts for one-fifth of all the cancers of the oral cavity. When the mortality rates are compared 25% of all the death due to oral cavity disease occur in the Indian continent. 4, 5

One of the major contributory factors for the development of cancer is tobacco chewing (6) . The other risk factors that contribute in the pathogenesis of oral cancers are consumption of alcohol in very high amounts, infections specially HPV, sharp tooth, sexually transmitted diseases, chronic inflammatory conditions of the tongue. 6, 7

Oral cancer though occurs across all socio economic groups, it seems to occur in a higher rate in the those who have a lower socio- economic status.6

Oral cancer has a long preclinical phase that consists of well-documented precancerous lesions. The precancerous lesions include homogeneous leukoplakia, nonhomogeneous leukoplakia, verrucous leukoplakia, erythroplakia, OSMF, lichen planus, and chronic traumatic ulcers.8 Visual screening of the oral cavity has been widely evaluated for its feasibility, safety, acceptability, accuracy to detect oral precancerous lesions and cancer, and efficacy and cost-effectiveness in reducing oral cancer mortality.9

The recent changes and the understanding of the pathological process that are involved in the disease process have paved a way to discover newer modalities in the treatment of cancer. In cancer of the tongue, surgery remains the most important modality in the treatment management. The mainstay of current therapy for oral cancer is surgery and radiation treatment.3, 4

The present day thought is that the best modality of management in each case needs to be individualized with expert opinion from various branches of oncology and allied people.

It is suggested that the cases need to be studied thoroughly by a team of experts that include competent individuals from the field of pathology, radiology, surgery, radiation oncology and medical oncology.10 All these individuals collective make up the reviewed by a tumour boards. The choice of modality depends on the location of the tumour, cosmetic and functional outcomes, age of the patient, associated illnesses, patient’s preference, and the availability of expertise.

Most early-stage oral cancers can be locally excised or treated with radiotherapy, with no or minimal functional and physical morbidity. Elective neck dissection to remove lymph nodes may be considered in selected cases, such as patients with stage I tongue cancer and stage II cancers at other oral sites, who may be at high risk of microscopic but not clinically evident involvement of the neck nodes (N0).11  

Locally advanced tumours are aggressive, and loco regional treatment failure rates are high. A combined modality approach integrating surgery, radiotherapy with or without chemotherapy, and planned and executed by a multidisciplinary team is always preferred.12, 13 

Conclusions

The mainstay of current. Exciting challenges include improving success rates of current therapy, reducing the morbidity of treatment, and to select the most appropriate treatment.

Source of Funding

None.

Conflict of Interest

None.

References

1 

Neha Gupta Ritu Gupta Arun Kumar Acharya Basavaraj Patthi Venkatesh Goud Somanath Reddy Changing Trends in oral cancer – a global scenarioNepal J Epidemiol2017646139

2 

Neha Gupta Ritu Gupta Arun Kumar Acharya Basavaraj Patthi Venkatesh Goud Somanath Reddy This work is licensed under a Creative Commons Attribution 4.0 International LicenseNepal J Epidemiol2017646139

3 

Michael B Barton Michael Frommer Jesmin Shafiq Role of radiotherapy in cancer control in low-income and middle-income countries Lancet Oncol2006758495

4 

Abdesslam Boutayeb Saber Boutayeb The burden of non communicable diseases in developing countriesInt J Equity Health200542

5 

S V Rao G Mejia K Roberts-Thomson R Logan Epidemiology of oral cancer in Asia in the past decade-an updateAsian Pacific J Cancer Preven20001410556777

6 

R Sankaranarayanan S W Duffy G Padmakumary N E Day M Krishan Nair Risk factors for cancer of the buccal and labial mucosa in Kerala, southern India.J Epidemiol Comm Health199044428692

7 

M N Shiu T H H Chen S H Chang L J Hahn Risk factors for leukoplakia and malignant transformation to oral carcinoma: a leukoplakia cohort in TaiwanBr J Cancer2000821118714

8 

Shalini Gupta OP Gupta Rajender Singh Anurag Tripathi Prevalence of oral cancer and pre-cancerous lesions and the association with numerous risk factors in North India: A hospital based studyNational J Maxillofac Surg20145142

9 

D Saranath SE Chang LT Bhoite RG Panchal IB Kerr AR Mehta High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in IndiaBr J Cancer19916345738

10 

S. V. Suryanarayana Deo Nootan K. Shukla Ashwin A. Kallianpur Bidhu K. Mohanti Sanjay P. Thulkar Aggressive multimodality management of locally advanced retromolar trigone tumorsHead Neck2013359126973

11 

Nicholas Kalavrezos Rishi Bhandari Current trends and future perspectives in the surgical management of oral cancerOral Oncol20104642932

12 

S. V. Suryanarayana Deo Nootan K. Shukla Ashwin A. Kallianpur Bidhu K. Mohanti Sanjay P. Thulkar Aggressive multimodality management of locally advanced retromolar trigone tumorsHead & Neck2013359126973

13 

V.M. Patil K. Prabhash V. Noronha A. Joshi V. Muddu S. Dhumal Neoadjuvant chemotherapy followed by surgery in very locally advanced technically unresectable oral cavity cancersOral Oncol2014501010004



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Original Article


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53-55


Authors Details

Rohan Chandra Gatty, Dinesh Shet, Reshmina Chandni Clara D’souza


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