IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain

Print ISSN: 2581-5210

Online ISSN: 2581-5229

CODEN : IIJAAL

IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain (IJASHNB) open access, peer-reviewed quarterly journal publishing since 2015 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing more...

  • Article highlights
  • Article tables
  • Article images

Article statistics

Viewed: 577

PDF Downloaded: 518


Get Permission Aggarwal and Gupta: Chronic tinnitus- a challenge for both the patient and the clinician


Introduction

The term “tinnitus” (from the Latin tinnire, to ring) describes a disorder in which noises are heard in the absence of corresponding external acoustic stimuli. Most experts distinguish between subjective and objective tinnitus.1 Objective tinnitus is a condition in which noises are generated within the body and transmitted to the ear, e.g., via spasms of the tensor muscle of the tympanic membrane. Objective tinnitus is rare and generally amenable to causally oriented treatment.1 Subjective nonpulsatile tinnitus is the most common and is only heard by the patient, whereas objective pulsatile tinnitus can sometimes be heard by an observer and is caused by an internal bodily vibration or noise2 Potential mechanisms of benefit include making tinnitus less noticeable, promoting habituation, distracting attention from tinnitus, relaxation, and promoting neuroplastic changes within the auditory system. Sound therapy can be provided by a range of media, including hearing aids, wearable sound generators, combination hearing aids, or bedside or tabletop sound generators.3

Epidemiology

Between 5% and 15% of the general population report tinnitus,4 and around 1% state that their quality of life is considerably impaired by their ear noises.5 accompanying diseases such as sleep disorders, depression, or anxiety disorders can have negative effects on almost all aspects of daily life.6, 7

Many physicians feel helpless when dealing with tinnitus,8 and this frequently leads to therapeutic nihilism.9 Some tinnitus patients report that the worst moment was not the onset of the ear noises, but rather when the treating physician informed them that there was “nothing more to be done” and that they would “just have to live with it.”

In actual fact there are many different treatment approaches available but lack of confidence in treating such patients is a big setback. Our intention with this article is to provide a practice-related treatment guideline for dealing with tinnitus patients.

Symptomatology

Clifford et al reported on the progression of tinnitus in a US Marine cohort, indicating that worsening tinnitus was associated with the presence of post-traumatic stress disorder and moderate/severe traumatic brain injury.10 Another study reported that severity of symptoms tended to be more severe, with tinnitus of longer duration among patients presenting for tinnitus therapy.11 Reduced bothersomeness of tinnitus immediately was noticed in Placebo groups in controlled clinical trials of tinnitus and up to 14-week postplacebo treatment.12

The sounds associated with most cases of tinnitus have been described as being analogous to cicadas, crickets, winds, falling tap water, grinding steel, escaping steam, fluorescent lights, running engines, and so on.13

Most tinnitus patients match their tinnitus to a pitch above 3 kHz.14 Most patients with both tinnitus and hearing loss report that the frequency of the tinnitus correlates with the severity and frequency characteristics of their hearing loss, and that the intensity of the tinnitus is usually less than 10 dB above the patient's hearing threshold at that frequency.13

There are cases reported where tinnitus vanishes during sleep but returns within a few hours further suggest that psychosomatic factors, such as neck muscle contractions occurring in an upright position or jaw clenching, play etiological roles.15

Because objective tinnitus (which is audible to another person) represents the semantic opposite of subjective tinnitus, a better nosological approach might be to use the term somatosound instead of objective tinnitus irrespective of whether the sounds are audible to others, reserving the term tinnitus for the perception of sound in the absence of any acoustic source. Thus, "tinnitus" would describe cases previously diagnosed as subjective tinnitus. Because objective tinnitus (which is audible to another person) represents the semantic opposite of subjective tinnitus, a better nosological approach might be to use the term somatosound instead of objective tinnitus irrespective of whether the sounds are audible to others, reserving the term tinnitus for the perception of sound in the absence of any acoustic source. Thus, "tinnitus" would describe cases previously diagnosed as subjective tinnitus.13

The individual degree of bother is crucial in deciding whether symptomatic treatment is indicated, to avoid pathologizing the ear noise in patients whose quality of life is not impaired to any great extent. It often seems helpful to mention the trials that have shown that even people without tinnitus tend to experience phantom noises in particular situations (e.g., complete auditory deprivation in a soundproof booth).16

Basis of knowledge

Till date, there is no valid objective measure to specify the presence of tinnitus or the effects of potential treatments. The trials that comment upon the quality of treatment are heterogeneous in the extreme, as indicated by all the available Cochrane meta-analyses on tinnitus.17, 18, 19, 20, 21, 22, 23 Accordingly, the efforts to improve quality standards in clinical trials of the treatment of tinnitus are a continous phenomenon.23, 24, 25, 26

Management Options

The treatment options for Tinnitus can be divided into two categories:

  1. Those aimed at directly reducing the intensity of tinnitus which include pharmacotherapy and electrical suppression27

  2. Those aimed at relieving the annoyance associated with tinnitus. These include pharmacotherapy, cognitive and behavioral therapy, sound therapy, habituation therapy,massage and stretching, and hearing aids. 28

Pharmacotherapy

There was a temporary suppression of tinnitus in a majority of patients with intravenous administration of the tension-dependent sodium-channel blocker lidocaine. 29, 30 There has been no single medicinal approach till date despite the researches and experimentation with large number of pharmaceutical agents. The indication for pharmacotherapy is therefore restricted to the treatment of comorbidities such as anxiety disorders, sleep disorders, and depression.

Several randomized clinical trials have revealed that only nortriptyline, amitriptyline, alprazolam, clonazepam, and oxazepam are more beneficial than placebo.Diazepam and flurazepam significantly change the tinnitus intensity.31 Tinnitus due to SOAEs can be diminished by aspirin.32 Flecainide, mexiletine, betahistine, carbamazepine, ginko extract, amylobarbiturate, baclofen, lamotrigine, misoprostol, zinc, cinnarizine, flunarizine, caroverine, eperisone, and melatonin are no more beneficial than placebo.27

Cognitive and behavioral therapy

Cognitive therapy deals with the ideation related to tinnitus and how to avoid the negative ideation, whereas behavioral therapy uses the systematic desensitization approach applied to many phobias.33 CBT helps to improve awareness and facilitate the modification of maladaptive patterns on the cognitive, emotional, and behavioral level.Behavioral therapy focuses on positive imagery, attention control, and relaxation training.33

Psychoeducation/counseling

Psychoeducative counseling is recommended as a basic component of management of tinnitus.34, 35 Fundamentally benign nature of idiopathic tinnitus if explained in an understandable and sympathetic is one of the best tools. Such a conversation between physician and patient represents the basis for establishment of constructive compensation and habituation mechanisms.

Individualized auditory stimulation

Tinnitus maskers—Tinnitus maskers generate either sounds from the natural environment or individually tailored noises. According to a Cochrane meta-analysis, the efficacy of tinnitus masking has been neither clearly proved nor disproved.17

Hearing Aids-Hearing aids represent another form of sound therapy that is usually beneficial to tinnitus patients with significant hearing loss. These compensate for hearing loss by improving the peripheral auditory input in the affected range of frequencies. The use of hearing aids can permanently reduce the neural activity responsible for tinnitus generation and perception,36 and usually represents the first intervention for patients with hearing impairment.37

Music therapy

Music therapy is a desensitization method that utilizes spectrally modified music based on hearing characteristics of each patient to allow the masking of tinnitus and to facilitate relaxation at a comfortable listening level. Hearing thresholds decline substantially above 3 kHz among many tinnitus patients, and hence the spectral modification should involve reducing the energy of lower frequency components of the music.38

Tinnitus retraining therapy

Tinnitus retraining therapy (TRT) comprises a combination of counseling and auditory stimulation by maskers or hearing aids. TRT consists of two components: retraining counseling and sound therapy. Retraining counseling aims to help patients to think of their tinnitus as a type of neutral sound.(39)However, TRT requires about 18 months to achieve observable stable effects, and this time-consuming treatment does not achieve satisfactory results in some patients. TRT requires patience and discipline from both the patient and a knowledgeable and experienced professional.39

Electrical suppression

Transcutaneous electrical nerve stimulation of areas of skin close to the ear increases the activation of the DCN via the somatosensory pathway and could augment the inhibitory role played by this nucleus on the CNS, thereby ameliorating tinnitus.40

Summary

The management of chronic tinnitus remains a challenge despite the availability of various forms of treatment, but there is no justification for therapeutic nihilism. No doctor today should say “there’s nothing we can do.” Cooperation among various disciplines is vital in the diagnosis and treatment of tinnitus.

Nevertheless, counseling represents an essential part of treatment, regardless of the management approach adopted for a particular patient. Most importantly, a strong doctor-patient relationship warrants successful management and high levels of satisfaction among patients.

Conflicts of Interest

All contributing authors declare no conflicts of interest.

Source of Funding

None.

References

1 

JJ Eggermont LE Roberts The neuroscience of tinnitusTrends Neurosci200427116768210.1016/j.tins.2004.08.010

2 

AJ Schleuning Management of the patient with tinnitus.Med Clin North Am199175612253710.1016/s0025-7125(16)30383-2.

3 

DJ Hoare GD Searchfield A El Refaie JA Henry Sound Therapy for Tinnitus Management: Practicable OptionsJ Am Acad Audiol2014251627510.3766/jaaa.25.1.5

4 

H J Hoffmann G Reed J B Snow Epidemiology of tinnitus. Tinnitus: Theory and ManagementHamilton: BC Decker2004641

5 

S Hébert B Canlon D Hasson LL Magnusson Hanson H Westerlund T Theorell Tinnitus Severity Is Reduced with Reduction of Depressive Mood – a Prospective Population Study in SwedenPLoS ONE201275e3773310.1371/journal.pone.0037733

6 

RFF Cima JWS Vlaeyen IHL Maes MA Joore LJC Anteunis Tinnitus Interferes With Daily Life Activities: A Psychometric Examination of the Tinnitus Disability IndexEar Hear20113256233310.1097/aud.0b013e31820dd411

7 

S Javaheri V Cohen I Libman V Sandor Life-threatening tinnitusLancet200035630810.1016/s0140-6736(00)02507-1

8 

DA Hall MJA Láinez CW Newman TG Sanchez M Egler F Tennigkeit Treatment options for subjective tinnitus: Self reports from a sample of general practitioners and ENT physicians within Europe and the USABMC Health Serv Res201111130210.1186/1472-6963-11-302

9 

B Langguth Tinnitus: the end of therapeutic nihilism.Lancet20123799830192634

10 

RE Clifford D Baker VB Risbrough M Huang KA Yurgil Impact of TBI, PTSD, and Hearing Loss on Tinnitus Progression in a US Marine CohortMil Med20191848394610.1093/milmed/usz016

11 

J L Stouffer R S Tyler P R Kileny L E Dalzell Tinnitus as a function of duration and etiology: counselling implicationsAm J Otol199112318894

12 

LG Duckert TS Rees Placebo effect in tinnitus managementOtolaryngol Head Neck Surg198492697706

13 

R A Dobie JB Snow Overview: suffering from tinnitusTinnitus: theory and managementBC Decker Inc200417

14 

D M Baguley C A Williamson D A Moffat RS Tyler Treating tinnitus in patients with otologic conditionsTinnitus treatment New York: Thieme20064150

15 

R A Levin J B Snow Somatic tinnitusTinnitus: theory and managementOntario: BC Decker Inc200410824

16 

M F Heller M Bergman Tinnitus Aurium in Normally Hearing PersonsAnn Otol Rhinol Laryngol1953621738310.1177/000348945306200107

17 

J Hobson E Chisholm A El Refaie Sound therapy (masking) in the management of tinnitus in adultsCochrane Database Syst Rev201211637110.1002/14651858.cd006371.pub3

18 

M Hilton E Stuart Ginkgo biloba for tinnitusCochrane Database Syst Rev20042CD00385210.1002/14651858.CD003852

19 

P Baldo C Doree R Lazzarini P Molin D J Mcferran Antidepressants for patients with tinnitusCochrane Database Syst Rev2006184CD00385310.1002/14651858.CD003853

20 

P Martinez-Devesa R Perera M Theodoulou A Waddell Cognitive behavioural therapy for tinnitusCochrane Database Syst Rev201089523310.1002/14651858.CD005233

21 

J S Phillips D Mcferran Tinnitus retraining therapy (TRT) for tinnitusCochrane Database Syst Rev201000733020103

22 

C E Hoekstra S P Rynja G A Van Zanten M M Rovers Anticonvulsants for tinnitusCochrane Database Syst Rev20113CD00796010.1002/14651858.CD007960

23 

Z Meng S Liu Y Zheng J S Phillips Repetitive transcranial magnetic stimulation for tinnitusCochrane Database Syst Rev201151010.1002/14651858.CD007946

24 

M Landgrebe F Zeman M Koller Y Eberl M Mohr J Reiter The Tinnitus Research Initiative (TRI) database: A new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcomeBMC Med Inform Decis Mak20101014210.1186/1472-6947-10-42

25 

B Langguth R Goodey A Azevedo A Bjorne A Cacace A Crocetti Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, RegensburgProg Brain Res200616652536

26 

B Langguth T Kleinjung M Landgrebe Tinnitus: the complexity of standardizationEval Health Prof20113442933

27 

RA Dobie A Review of Randomized Clinical Trials in TinnitusLaryngoscope1999109812021110.1097/00005537-199908000-00004

28 

R S Tyler R S Tyler Neurophysiological models, psychological models, and treatments for tinnitusTinnitus treatment. New York: Thieme2006122

29 

J M Israel J S Connelly S T McTigue R E Brummett J Brown Lidocaine in the Treatment of Tinnitus Aurium: A Double-blind StudyArch Otolaryngol1982108847130886-447010.1001/archotol.1982.00790560009003

30 

P S Melding R J Goodey P R Thorne The use of intravenous lignocaine in the diagnosis and treatment of tinnitusJ Laryngology Otol19789221152110.1017/s002221510008511x

31 

K Murai R S Tyler L A Harker J L Stouffer Review of pharmacologic treatment of tinnitusAm J Otol19921345464

32 

M J Penner Aspirin Abolishes Tinnitus Caused by Spontaneous Otoacoustic Emissions: A Case StudyArch Otolaryngol Head Neck Surg19891157871510.1001/archotol.1989.01860310109034

33 

R S Tyler W Noble J Preece C C Dunn S A Witt J Snow Psychological treatments for tinnitusTinnitus: theory and managementBC Decker IncOntario200431425

34 

G Searchfield J Magnusson G Shakes E Biesinger O Kong A Moller Counceling and psycho-education for tinnitus managementTextbook of tinnitus. Springer. (1st edn.) Springer2011535536

35 

H P Zenner M Pfister N Birbaumer Tinnitus sensitization: Sensory and psychophysiological aspects of a new pathway of acquired centralization of chronic tinnitusOtol Neurotol200627105463

36 

R L Folmer W H Martin Y Shi L L Edlefsen RS Tyler Tinnitus sound therapyTinnitus treatment. New York: Thieme200617686

37 

G D Searchfield R S Tyler Hearing aids and tinnitusTinnitus treatmentNew York: Thieme200616175

38 

P B Davis R S Tyler Music and the acoustic desensitization protocol for tinniusTinnitus treatmentNew York: Thieme200614660

39 

A H Lockwood R J Salvi R F Burkard TinnitusN Eng J Med2002347129041010.1056/nejmra013395

40 

A Herraiz A Toledano I Diges Trans-electrical nerve stimulation (TENS) of somatic tinnitusProg Brain Res200716638994



jats-html.xsl


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Article type

Review Article


Article page

12-15


Authors Details

Priyanka Aggarwal, Ashish Gupta


Article History

Received : 13-03-2021

Accepted : 19-03-2021


Article Metrics


View Article As

 


Downlaod Files